Liu J, Shiono J, Shimizu K, Kukita A, Kukita T, Kondo R (2009) Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. Bioorganic & Medicinal Chemistry Letters 19, 2154-2157.

Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5alpha-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.

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