Cronic Inflammation // Inflamación Crónica
RELATED ARTICLES/ARTÍCULOS RELACIONADOS
Title/Título: The Biologically Active Constituents of Ganoderma lucidum (FR.) KARST. Histamine Release-Inhibitory Triterpe.
Author(s)/Autor(es): Hiroshi K. The Biologically Active Constituents of Ganoderma lucidum (FR.) KARST. Histamine Release-Inhibitory Triterpe; Chem. Pharm. Bull., 33(4), 1367-1374 (1985).
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Title/Título: Anti-inflammatory and Anti-nociceptive Activities of Ganoderma lucidum Occurring in South India.
Author(s)/Autor(es): Sheena N., Ajith TA., Janardhanan KK. Anti-inflammatory and Anti-nociceptive Activities of Ganoderma lucidum Occurring in South India. Pharmaceutical Biology 2003, Vol. 41, No. 4, Pages 301-304.
Abstract/Resumen: The seventy percent methanol and ethyl acetate extracts of Ganoderma lucidum Reishi, occurring in South India, were investigated for anti-nociceptive and anti-inflammatory activities in animal models. Both extracts produced significant dose-dependent inhibition of carrageenan-induced acute and formalin-induced chronic inflammation in mice. The extracts also showed marked analgesic activity comparable to the standard reference drug, diclofenac. The methanol extract possessed significantly higher activity than the ethyl acetate extract. These findings indicate the potential therapeutic use of extracts of South Indian G. lucidum as an antiinflammatory and anti-nociceptive agent.
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Title/Título: Anti-inflammatory triterpenoids from mysterious mushroom Ganoderma lucidum and their potential possibility in modern medicine.
Author(s)/Autor(es): Patocka J. Anti-inflammatory triterpenoids from mysterious mushroom Ganoderma lucidum and their potential possibility in modern medicine. Acta Medica (Hradec Kralove). 1999;42(4):123-5.
Abstract/Resumen: Ganoderma lucidum, a mushroom long used in the East for a broad range of disorders, contains numerous pharmacologically active compounds. Very important of them are highly oxygenated anti-inflammatory triterpenes, which are the aim of this mini-review.
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Title/Título: Suppressive effects of Ganoderma lucidum on proliferation of peripheral blood mononuclear cells.
Author(s)/Autor(es): Kim RS., Kim HW., Kim BK. Suppressive effects of Ganoderma lucidum on proliferation of peripheral blood mononuclear cells. Mol Cells. 1997 Feb 28;7(1):52-7.
Abstract/Resumen: The basidiocarps of Ganoderma lucidum have been used for prevention and treatment of various diseases in the Orient. Methanolic extracts of this mushroom were applied to human peripheral blood mononuclear cell (PBMC) culture systems in the presence of various immunostimulating or immunosuppressive agents. Phytohemagglutinin-induced cell proliferation was reduced to 14% of that of the control by a GLE fraction that is the neutral component of the methanolic extracts of the carpophores. 12-O-tetradecanoylphorbol 13- acetate (TPA)-induced cell proliferation was inhibited by the fractions of GLA, GLC, GLE and GLG. However none of these fractions inhibited proliferation of the PBMCs stimulated with TPA plus ionomycin (IM). Treatment of the PBMCs with cyclosporin A (CsA) led to blockage of the cell proliferation to 9% of that of the control. When the cells were cultured with the methanolic fractions in the presence of CsA, concentration dependent inhibition of the cell proliferation was observed by the addition of GLE and GLG fractions. On the contrary, the GLH fraction recovered the CsA induced inhibition of the cell proliferation. Taken together, among the methanolic fractions, GLE showed the highest inhibitory activity. This fraction might inhibit the protein kinase C signal pathway and accelerate the CsA signal pathway.
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