Cytotoxic activity of ergosta-4,6,8(14),22-tetraen-3-one from the sclerotia of Polyporus umbellatus

Bulletin of the Korean Chemical Society

The isolation and identification of a cytotoxic compd. from the sclerotia of Polyporus umbellatus are described. The structure of this compd. was elucidated by FT-IR, 1-D and 2-D NMR spectroscopy and its cytotoxic activities against human cancer cell lines were demonstrated. Results indicated that the structure of the compd. is ergosta-4,6,8(14),22-tetraen-3-one (ergone). [on SciFinder (R)]