Supplemental anti-fatigue effects of Cordyceps sinensis (Tochu-Kaso) extract powder during three stepwise exercise of human

The purpose of this study was to examine the effectiveness of the cultured Cordyceps sinensis (Cs, supplement) powder during exhaustive running of human comparing with the placebo (control). These supplements were given to 36 male sedentary subjects over period of 2 weeks. During the exercise, following bio-signals were measured such as the respiratory variables (VO2, VCO2, VE), the blood pressure (BP), the heart rate (HR), and the lactic acid (LA). In addition, their storing urine for one night was inspected about the catecholamine (CA, Adr, NorA, Dop) and the cortisol hormone (17-KA-S and 17-OHCS) at the pre- and the post-ingesting with those supplements. The changing ratio calculating between the pre- and the post-variables Of VO2/kg (5.2.+-.0.1 & 4.8.+-.0.1ml), VE (12.0.+-.0.2 & 11.0.+-.0.2L), and LA (6.1.+-.2.1 & 5.2.+-.2.6 mmol/dl) had decreased to lower percentages at the recovery period from the exercise test than those of CON, significantly (p<0.01). Futhermore, concentration of the total CA (1.19.+-.0.51 & 1.29.+-.0.49mg/L), Adr (13.5.+-.1.2 & 17.7.+-.1.9.MU.g/L), NorA (127.4.+-.8.1 & 130.0.+-.8.5.MU.g/L), Dop (1.06.+-.0.1 & 1.14.+-.0.4mg/L), 17-OHCS/creatinine (4.42.+-.0.30 & 4.2.+-.0.31), and 17-KS-G/creatinine (3.18.+-.0.09 & 3.06.+-.0.07) showed changes of significant difference related to the placebo (p<0.05). There have been appeared an augmentation of the energy generation and the anti-fatigue ability intaking with this supplement during the exercise test. During this prolonged exercise, ingesting with this Cs might elicit the superior efficiency and the economical function on the energy metabolism. (author abst.)

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